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NDI-101150

CAT: 0013-GTR19259603-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259603-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NDI-101150​ is a highly selective, orally bioavailable small-molecule inhibitor targeting hematopoietic progenitor kinase 1 (HPK1/MAP4K1), a key negative regulator of T-cell signaling. This compound demonstrates potent immunomodulatory activity by enhancing T-cell activation and proliferation, while simultaneously exhibiting robust antitumor efficacy in preclinical models. Its mechanism of action involves disrupting HPK1-mediated suppression of immune responses, leading to improved T-cell function and sustained inhibition of tumor progression. With its favorable pharmacokinetic profile and specificity for HPK1, NDI-101150 represents a promising therapeutic candidate for cancer immunotherapy, particularly in settings where T-cell activity is compromised.
CAS Number
2628486-22-4
Purity
>98%
Smiles
C1 (=O) C2=C (C (C3N4C (=NC=3) C=C (F) C=C4) =CC=C2NC2=NC (CN (C) C) =C ([C@@H]3CCOC3) C=C2) CN1
Molecular Formula
C27H27FN6O2
Molecular Weight
486.540688753128
Notes
For research use only.

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