ONT-093

• Description :

  ONT-093 (OC 144-093) is a potent and orally active inhibitor of P-glycoprotein pump. ONT-093 inhibits P-gp-mediated ATPase activity with an IC50 of 0.16 μM. ONT-093 can inhibit drug efflux and increase bioavailability. ONT-093 reverses cancer cells multidrug resistance to chemotherapeutic drugs. ONT-093 can be used for the researches of cancer and infection, such as colon cancer and malarial [1][2][3].

• Product Name Alternative :

  OC 144-093; OC 144093

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  P-glycoprotein

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/ont-093.html

• Purity :

  99.21

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

• Smiles :

  CC(C)NC1=CC=C(C2=C(C3=CC=C(NC(C)C)C=C3)N=C(C4=CC=C(/C=C/COCC)C=C4)N2)C=C1

• Molecular Formula :

  C32H38N4O

• Molecular Weight :

  494.67

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Newman MJ, et al. Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Res. 2000 Jun 1;60 (11) :2964-72.|[2]Chi KN, et al. A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer. Invest New Drugs. 2005 Aug;23 (4) :311-5.|[3]Sanchez CP, et al. Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum. Mol Microbiol. 2008 Nov;70 (4) :786-98.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [216227-54-2]