ONT-993

• Description :

  ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM) [1].

• Product Name Alternative :

  AR 00440993

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Cytochrome P450

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ont-993.html

• Purity :

  99.85

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OCC1(C)N=C(NC2=CC3=C(NC4=CC=C(C(C)=C4)OC5=CC6=NC=NN6C=C5)N=CN=C3C=C2)OC1

• Molecular Formula :

  C26H24N8O3

• Molecular Weight :

  496.52

• Precautions :

  H302

• References & Citations :

  [1]Sun H, et al. Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl. Cancer Chemother Pharmacol. 2022 Jun;89 (6) :737-750.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CYP2

• CAS Number :

  [937263-81-5]