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Propargyl-PEG2-amine

CAT: 0804-HY-W051634-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W051634-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2]. Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
944561-44-8
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/propargyl-peg2-amine.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCOCCOCC#C
Molecular Formula
C7H13NO2
Molecular Weight
143.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A.|[2]Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

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