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Bis-propargyl-PEG2

CAT: 0804-HY-133191-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-133191-01Size:1 g
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Description
Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
126422-57-9
UNSPSC
12352211
Hazard Statement
H227
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/bis-propargyl-peg2.html
Purity
98.08
Solubility
10 mM in DMSO
Smiles
C#CCOCCOCCOCC#C
Molecular Formula
C10H14O3
Molecular Weight
182.22
Precautions
H227
References & Citations
[1]Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13 (10) :3018-30.|[2]Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74 (27), 3527–3533.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

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