Propargyl-PEG2-Tos

• Description:

  Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/propargyl-peg2-tos.html

• Purity:

  99.85

• Solubility:

  10 mM in DMSO

• Smiles:

  C#CCOCCOS(C1=CC=C(C)C=C1)(=O)=O

• Molecular Formula:

  C12H14O4S

• Molecular Weight:

  254.31

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PEG Linkers

• CAS Number:

  145916-41-2