Ethionamide

CAT: 0804-HY-B0276-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-B0276-02Size:10 mM - 1 mL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity[1][2][3][4].

CAS Number

536-33-4

Product Name Alternative

2-Ethylthioisonicotinamide

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Ethionamide.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

S=C(C1=CC(CC)=NC=C1)N

Molecular Formula

C8H10N2S

Molecular Weight

166.25

Precautions

H302, H361

References & Citations

[1]Vannelli, T.A., A. Dykman, and P.R. Ortiz de Montellano, The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem, 2002. 277 (15) : p. 12824-9.|[2]Quemard, A., G. Laneelle, and C. Lacave, Mycolic acid synthesis: a target for ethionamide in mycobacteria? Antimicrob Agents Chemother, 1992. 36 (6) : p. 1316-21.|[3]Marilyn C Henderson, et al. Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol. 2008 Dec 15;233 (3) :420-7.|[4]Amy L Palmer, et al. Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse. Pharmaceuticals (Basel) . 2012;5 (11) :1147-59.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Chemical Information

Ethionamide

Ethionamide can cause developmental toxicity according to state or federal government labeling requirements.

CAS Number	536-33-4
PubChem CID	2761171
IUPAC Name	2-ethylpyridine-4-carbothioamide
Molecular Formula	C8H10N2S
Molecular Weight	166.25
XLogP	1.1
Topological Polar Surface Area	71
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	11
Formal Charge	0
Complexity	147

SMILES

CCC1=NC=CC(=C1)C(=S)N

InChI

InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

InChIKey

AEOCXXJPGCBFJA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 536-33-4

CID: 2761171

Formula: C8H10N2S

MW: 166.25

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	166.25
XLogP3	1.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	166.05646950
Monoisotopic Mass	166.05646950
Topological Polar Surface Area	71 Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	147
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-117543	Ethonafide

Alternative Products

Catalog	Name
A8429-1000	Ethionamide

Ethionamide

Chemical Information

Related Products

Alternative Products

Popular Products