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Physostigmine (hemisulfate)

CAT: 0804-HY-N2320-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2320-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning[1][2][3][4].
CAS Number
64-47-1
Product Name Alternative
Eserine (hemisulfate)
UNSPSC
12352005
Hazard Statement
H300+H330
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/physostigmine-hemisulfate.html
Purity
99.0
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
CN1[C@](N(C)CC2)([H])[C@]2(C)C3=C1C=CC(OC(NC)=O)=C3.O=S(O)(O)=O.[1/2]
Molecular Formula
C15H21N3O2.1/2H2O4S
Molecular Weight
324.38
Precautions
P260-P264-P270-P271-P284-P304+P340-P330-P403+P233-P405-P501
References & Citations
[1]Jonathan D Kenny, et al. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov;123 (5) :1210-1219.|[2]Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42 (3) :188‐189.|[3]Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl) . 2005;181 (1) :145‐152.|[4]Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings? Curr Opin Pediatr. 2007;19 (2) :201‐205.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
AChE

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