Physostigmine

• Description:

  Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

• Product Name Alternative:

  Eserine

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H317, H331

• Target:

  Cholinesterase (ChE)

• Type:

  Natural Products

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/physostigmine.html

• Purity:

  99.92

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CN1[C@](N(C)CC2)([H])[C@]2(C)C3=C1C=CC(OC(NC)=O)=C3

• Molecular Formula:

  C15H21N3O2

• Molecular Weight:

  275.35

• Precautions:

  H301, H315, H317, H331

• References & Citations:

  [1]Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42 (3) :188‐189.|[2]Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl) . 2005;181 (1) :145‐152.|[3]Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings? Curr Opin Pediatr. 2007;19 (2) :201‐205.|[4]Jonathan D Kenny, et al. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov;123 (5) :1210-1219.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 4

• Isoform:

  AChE

• CAS Number:

  [57-47-6]