Hemicholinium 3

• Description :

  Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh) [1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively[2].

• Product Name Alternative :

  Hemicholinium (dibromide)

• UNSPSC :

  12352005

• Hazard Statement :

  H301+H311+H331, H315, H319, H335

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/hemicholinium-3.html

• Concentration :

  10mM

• Purity :

  99.85

• Solubility :

  H2O : 33.33 mg/mL (ultrasonic)

• Smiles :

  C[N+]1(C)CC(C2=CC=C(C3=CC=C(C4(O)C[N+](C)(C)CCO4)C=C3)C=C2)(O)OCC1.[Br-].[Br-]

• Molecular Formula :

  C24H34Br2N2O4

• Molecular Weight :

  574.35

• Precautions :

  H301+H311+H331, H315, H319, H335

• References & Citations :

  143

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [312-45-8]