Hemicholinium 3

• Description:

  Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh) [1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively[2].

• Product Name Alternative:

  Hemicholinium (dibromide)

• UNSPSC:

  12352005

• Hazard Statement:

  H301+H311+H331, H315, H319, H335

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hemicholinium-3.html

• Concentration:

  10mM

• Purity:

  99.85

• Solubility:

  H2O : 33.33 mg/mL (ultrasonic)

• Smiles:

  C[N+]1 (C) CC (C2=CC=C (C3=CC=C (C4 (O) C[N+] (C) (C) CCO4) C=C3) C=C2) (O) OCC1.[Br-].[Br-]

• Molecular Formula:

  C24H34Br2N2O4

• Molecular Weight:

  574.35

• Precautions:

  H301+H311+H331, H315, H319, H335

• References & Citations:

  143

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  312-45-8