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P62-RNF168 agonist-1

CAT: 0804-HY-151799-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-151799-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner[1].
CAS Number
2765180-17-2
UNSPSC
12352005
Target
Apoptosis; E1/E2/E3 Enzyme; p62
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-81.html
Purity
98.62
Solubility
DMSO : ≥ 60 mg/mL
Smiles
NC1=C2C(C=CC(C3=CN(C4=CC(OC)=C(C(OC)=C4)OC)N=N3)=C2)=NC(N)=N1
Molecular Formula
C19H19N7O3
Molecular Weight
393.40
References & Citations
[1]Wang FC, et al. A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62. J Med Chem. 2022 Nov 4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
PPL00549-2bPcDNA3.1-p62
512437P62/SQSTM1 (P62, Sequestosome 1, SQSTM1, Ubiquitin Binding Protein p62) discontinued
GTR19241208-01P62-ZZ ligand 1
PVTB00549-2bpcDNA3.1-p62 Plasmid
BZ17763HA-p62 (1-385AA)
NBP1-76324CL1Rabbit Polyclonal RNF168 Antibody [CoraFluor 1]
BZ18306HA-P62 (1-227aa255-440aa)
PVT17530HA-P62(1-227aa Plasmid
QY-E05787Human Sequestosome-1 (P62; SQSTM1)
PVT16960HA-p62(1-385AA) Plasmid

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