CM-545

• Description:

  CM-545, the cis-isomer of CM-414 (HY-119316), is a dual inhibitor of PDE5, HDAC1, HDAC2, HDAC3, and HDAC6 with pIC50 values of 7.47, 6.65, 6.14, 6.55, and 6.84, repectively[1].

• UNSPSC:

  12352005

• Target:

  HDAC; Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cm-545.html

• Smiles:

  O=C ([C@H]1C[C@@H] (CC2=CC=C (OCC) C (C3=NC4=C (N (C) N=C4CCC) C (N3) =O) =C2) C1) NO

• Molecular Formula:

  C23H29N5O4

• Molecular Weight:

  439.51

• References & Citations:

  [1]Mar Cuadrado-Tejedor, et al. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology. 2017 Jan;42 (2) :524-539.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC1; HDAC2; HDAC3; HDAC6; PDE5

• CAS Number:

  1624792-70-6