BAY-545

CAT: 0804-HY-111767-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-111767-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2B adenosine receptor in cells, respectively, and a Ki of 97 nM for human A2B adenosine receptor, with more selectivity over A1, A2A, and A3 adenosine receptor[1].
CAS Number
[1699717-32-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BAY-545.html
Purity
98.18
Solubility
DMSO : ≥ 150 mg/mL
Smiles
CCN1C(N(CCC(F)(F)F)C2=C(C(C)=C(C(N3CCC(O)CC3)=O)S2)C1=O)=O
Molecular Formula
C18H22F3N3O4S
Molecular Weight
433.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Härter M, et al. Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure. Eur J Med Chem. 2019 Feb 1;163:763-778.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
C17818BAY-545
A20116-1BAY-545 1mg
A20116-5BAY-545 5mg
A20116-10BAY-545 10mg
A20116-200BAY-545 200mg
A20116-25BAY-545 25mg
A20116-50BAY-545 50mg
A20116-100BAY-545 100mg
A20116-10mM-DBAY-545 10mM * 1mL in DMSO
TRC-O671000-250MGOR 545

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