RI-STAD-2

• Description :

  RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA) . RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer[1].

• UNSPSC :

  12352209

• Target :

  PKA

• Type :

  Peptides

• Related Pathways :

  Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ri-stad-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@](NC1=O)(C)CCC/C=C/CCC[C@](C(N[C@H](C(N[C@H](C(N[C@H]1C)=O)CC2=CC=C(O)C=C2)=O)CCC(N)=O)=O)(C)NC([C@@H](NC(COCCOCCOCCN)=O)CC(C)C)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)CCC(N)=O

• Molecular Formula :

  C109H181N25O35

• Molecular Weight :

  2401.75

• References & Citations :

  [1]Autenrieth K, et al. Defining A‐kinase anchoring protein (AKAP) specificity for the protein kinase A subunit RI (PKA‐RI) [J]. Chembiochem, 2016, 17 (8) : 693-697.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported