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RI (dl) -2

CAT: 0804-HY-126972-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126972-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RI (dl) -2 blocks RAD51’s D-loop activity in biochemical systems with an IC50 value of 11.1 µM and inhibits homologous recombination (HR) activity with an IC50 value of 3.0 µM. RI (dl) -2 inhibits HR-mediated repair of DNA double strand breaks and sensitizes different cancer cell lines[1].
CAS Number
1902146-75-1
UNSPSC
12352005
Target
RAD51
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ri-dl-2.html
Solubility
10 mM in DMSO
Smiles
CCNC(C=C1)=CC=C1C2=NC3=C(N4C=CC=C42)C=CC=C3
Molecular Formula
C19H17N3
Molecular Weight
287.36
References & Citations
[1]Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59 (10) :4511-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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