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RI-1

CAT: 0804-HY-15317-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15317-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells[1].
CAS Number
415713-60-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RAD51
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RI-1.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C(N1CCOCC1)=C2Cl)N(C3=CC=C(Cl)C(Cl)=C3)C2=O
Molecular Formula
C14H11Cl3N2O3
Molecular Weight
361.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Budke B, et, al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug;40 (15) :7347-57.|[2]Shi Y, et, al. DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia. 2019 Jun;21 (6) :533-544.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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