MSC-1186

• Description :

  MSC-1186, a chemical probe, is a highly selective pan-SRPK inhibitor. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 can be used for the research of cancer[1].

• UNSPSC :

  12352005

• Target :

  SRPK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/msc-1186.html

• Concentration :

  10mM

• Purity :

  98.95

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  CS(=O)(N(C1=NC=CC=C1CNC2=NC(C3=NC4=C(F)C(Cl)=CC=C4N3)=NC=C2)C)=O

• Molecular Formula :

  C19H17ClFN7O2S

• Molecular Weight :

  461.90

• References & Citations :

  [1]Martin Schröder, et al. MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. J Med Chem. 2022 Dec 14.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2871698-23-4]