MSC-4106

• Description :

  MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model[1].

• UNSPSC :

  12352005

• Target :

  YAP

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/msc-4106.html

• Concentration :

  10mM

• Purity :

  99.87

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC2=C(N(C3=CC=C(C(F)(F)F)C=C3)C4=NN(C)C=C42)C=C1)O

• Molecular Formula :

  C18H12F3N3O2

• Molecular Weight :

  359.30

• References & Citations :

  [1]Timo Heinrich, et al. Optimization of TEAD P-site binding fragment hit into in vivo active lead MSC-4106. J. Med. Chem. 2022, 65, 13, 9206–9229.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  YAP/TAZ-TEAD

• CAS Number :

  [2738542-58-8]