Antifolate C1

• Description :

  Antifolate C1 (AGF 94) is a GARFTase inhibitor. Antifolate C1 inhibits de novo purine biosynthesis. Antifolate C1 inhibits cell proliferation[1].

• Product Name Alternative :

  AGF 94

• UNSPSC :

  12352005

• Target :

  Antifolate

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/antifolate-c1.html

• Smiles :

  O=C1C2=C(NC(N)=N1)NC(CCCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)=C2

• Molecular Formula :

  C19H21N5O6S

• Molecular Weight :

  447.46

• References & Citations :

  [1]O'Connor C, et al. Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. Sci Rep. 2021 Mar 18;11 (1) :6389.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [136784-51-5]