Antifolate C1

• UNSPSC Description:

  Antifolate C1 (AGF 94) is a GARFTase inhibitor. Antifolate C1 inhibits de novo purine biosynthesis. Antifolate C1 inhibits cell proliferation[1].

• Target Antigen:

  Antifolate

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antifolate-c1.html

• Smiles:

  O=C1C2=C(NC(N)=N1)NC(CCCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)=C2

• Molecular Weight:

  447.46

• References & Citations:

  [1]O'Connor C, et al. Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. Sci Rep. 2021 Mar 18;11(1):6389.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4