Antifolate agent 1

CAT: 0804-HY-175428Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175428Size:1 Each
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Description
Antifolate agent 1 (Compound 1) is an antifolate agent with one-carbon bridge. Antifolate agent 1 lacks RFC transport and has no affinity for FRα and FRβ and no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control for the development of folate receptor-targeting antifolates[1].
CAS Number
[518063-75-7]
UNSPSC
12352005
Target
Antifolate
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1C2=C(NC(N)=N1)NC(CC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=C2
Molecular Formula
C19H19N5O6
Molecular Weight
413.38
References & Citations
[1]Deng Y, et al. Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. J Med Chem. 2008 Aug 28;51 (16) :5052-63. |[2]Deng Y, et al. Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. J Med Chem. 2008 Aug 28;51 (16) :5052-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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