Rabbit anti Human Small ubiquitin-related modifier 1 (SUMO-1)

• Background:

  Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4

• Synonyms:

  Ubiquitin-like Protein SMT3C, Sentrin, Ubiquitin-homology Domain Protein PIC1, Ubiquitin-like Protein UBL1. GAP-modifying Protein 1, GMP-1

• UniProt:

  P63165

• Host:

  Rabbit

• Species Reactivity:

  Human

• Isotype:

  IgG

• Conjugation:

  Affinity Purified

• Type:

  Antigen Immunoaffinity Purified Polyclonal

• Applications:

  WB, ELISA

• Field of Research:

  Signal Transduction

• Purification Method:

  Antigen Immunoaffiinity Purification

• Assay Principle:

  Antibody can be used for Western blotting (1:400 dilution) and immunohistochemistry (10-15µg/mL). Optimal concentration should be evaluated by serial dilutions.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Saitoh, H., et al. 'SUMO-1: wrestling with a new ubiquitin-related modifier.' Trends Biochem Sci 1997; 22(10):374-376 2. Muller, S., et al. 'Conjugation with the ubiquitin-related modifier SUMO-1 regulated the partitioning of PML within the nucleus.' EMBO J 1998; 17(1):61-70 3. Navascues J., et al. 'SUMO-1 transiently localizes to Cajal bodies in mammalian neurons.' J Struct Biol 2008; 163(2):137-146.

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB

• CAS Number:

  9007-83-4