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Gamma-Mangostin

CAT: 0804-HY-N1957-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1957-01Size:1 mg
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Description
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4) -binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM) . Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes[1][2][3][4][5].
CAS Number
31271-07-5
Product Name Alternative
γ-Mangostin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; COX; Transthyretin (TTR)
Type
Natural Products
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gamma-mangostin.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
Molecular Formula
C23H24O6
Molecular Weight
396.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357 (1) :25-31.|[2]Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.|[3]Husen S A, et al. Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice. 2018 IOP Conf. Ser.: Earth Environ. Sci. 217 012031|[4]Husen S A, et al. Renal protective effects of gamma-mangostin in streptozotocin-induced diabetic mice[J]. Indian Journal of Forensic Medicine & Toxicology, 2020, 14 (3) : 1251-1256.|[5]Chen, S P, Lue, et al.Gamma-mangostin of Garcinia mangostana peels ameliorates hyperglycemia in synergism of insulin. The FASEB Journal, 33: 694.11-694.11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; COX-2; α-1 microglobulin

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