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Beta-Mangostin

CAT: 0804-HY-N0941-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0941-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) [1][2][3][4].
CAS Number
20931-37-7
Product Name Alternative
β-Mangostin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/beta-Mangostin.html
Purity
99.84
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(OC)=C2
Molecular Formula
C25H28O6
Molecular Weight
424.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Chien-Feng Huang, et al.β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. Environ Toxicol. 2017 Nov;32 (11) :2360-2370.|[2]Fatima Abdelmutaal Ahmed Omer, et al. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest. Tumour Biol. 2017 Nov;39 (11) :1010428317731451.|[3]K Likhitwitayawuid, et al. Antimalarial xanthones from Garcinia cowa. Planta Med. 1998 Feb;64 (1) :70-2.|[4]Sunit Suksamrarn, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) . 2003 Jul;51 (7) :857-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium

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