Naspm

• Description :

  Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

• Product Name Alternative :

  1-Naphthylacetyl spermine

• UNSPSC :

  12352005

• Target :

  IGluR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Naspm.html

• Purity :

  96.30

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1

• Molecular Formula :

  C22H34N4O

• Molecular Weight :

  370.53

• References & Citations :

  [1]Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29 (1) :27-36.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AMPA Receptor

• Citation 01 :

  Cell Rep. 2023 Dec 3;42 (12) :113551.|iScience. 2023 Mar 3;26 (4) :106322.|J Headache Pain. 2022 Aug 10;23 (1) :98.|Neurobiol Dis. 2024 May:194:106471.|Neuroscience. 2021 Nov 1:475:220-228.|Toxicol In Vitro. 2017 Oct:44:57-65.|Cell Rep. 2020 Nov 10;33 (6) :108369.

• CAS Number :

  [122306-11-0]