K 01-162

CAT: 0804-HY-14533-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14533-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease[1][2].
CAS Number
[677746-25-7]
Product Name Alternative
K162
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/K-01-162.html
Purity
98.0
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
BrC1=CC(CC2=C3C=CC(N(C)C)=C2)=C3C=C1
Molecular Formula
C15H14BrN
Molecular Weight
288.18
References & Citations
[1]Li J, et al. Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J. 2011 Feb 16;100 (4) :1076-82.|[2]Hong HS, et al. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct;31 (10) :1690-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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