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Antifungal agent 140

CAT: 0804-HY-179518Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179518Size:1 Each
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Description
Antifungal agent 140 (compound 5p) is a potent antifungal agent with broad-spectrum antifungal activity. Antifungal agent 140 exerts a dual mechanism by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and the ergosterol biosynthesis pathway. Antifungal agent 140 enhances survival, reduces fungal load in the kidneys, and strengthens host immune responses in a murine model of systemic candidiasis. Antifungal agent 140 can be used for research of resistant fungal infections[1].
UNSPSC
12352005
Target
Fungal; PKA; Ras
Related Pathways
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Infection
Smiles
FC1=C(C(CNC(CCN2CCN(C3=C4C=CC=CC4=CC=C3)CC2)=O)(O)CN5N=CN=C5)C=CC(F)=C1
Molecular Formula
C28H30F2N6O2
Molecular Weight
520.57
References & Citations
[1]Xu Z, et al. Exploration of piperazine-azole hybrids as antifungal agents against drug-resistant Candida albicans. Bioorg Chem. 2025 Nov;166:109181.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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