PI3K-IN-11

PI3K-IN-11

• CAS Number: 884539-95-1
• UNSPSC Description: PI3K-IN-11 (compound 13) is a PI3K inhibitor, which selectively inhibits PI3Kα, PI3Kβ, PI3K, and PI3Kδ (IC50s=6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50=2.9 μM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 μg/mL. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.
• Target Antigen: PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-in-11.html
• Smiles: O=C1/C(C([C@]2(C)[C@@H](COC)O1)=C(O)C(C3=C2[C@H](OC(C)=O)C[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=O)=C/N(CCCN(C)C)C
• Molecular Weight: 546.65
• References & Citations: [1]Zask, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: Potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J. Med. Chem. 51(5), 1319-1323 (2008).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported