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Bisdemethoxycucurmin

CAT: 0804-HY-N0007A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0007A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases[1][2][3].
CAS Number
24939-16-0
Product Name Alternative
Curcumin III; Didemethoxycurcumin
UNSPSC
12352005
Hazard Statement
H315, H319
Target
DNA/RNA Synthesis; Ferroptosis; P-glycoprotein
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bisdemethoxycucurmin.html
Purity
98.96
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C=C2
Molecular Formula
C19H16O4
Molecular Weight
308.33
Precautions
H315, H319
References & Citations
[1]Zhang P, et al. Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis. Biomed Pharmacother. 2023 Sep;165:115252.|[2]Nagabhushan, et al. Curcumin as an inhibitor of cancer. Journal of the American College of Nutrition 11.2. 1992. 192-198.|[3]Chearwae W, et al. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem Pharmacol. 2004 Nov 15;68 (10) :2043-52.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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