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LOXL3 rabbit pAb

CAT: 0855-ES15132-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15132-01Size:50 µL
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Background
This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016]
Description
This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016],
UniProt
P58215
Swiss Prot
P58215
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human LOXL3 AA range: 130-180
Target
LOXL3
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Secreted, extracellular space . Cytoplasm . Nucleus . It is unclear how LOXL3 is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (LOXL2) also has intracellular and extracellular localization despite the presence of a signal sequence (PubMed:28065600) . .; [Isoform 1]: Secreted, extracellular space .; [Isoform 2]: Cytoplasm . Secreted, extracellular space .
Gene ID (Human)
84695

UniProtKB · P58215

Lysyl oxidase homolog 3

LOXL3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P58215
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LOXL3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.4.3.-, 1.4.3.13
Processing
Precursor
Secondary accessions
D6W5J1, Q2EHP2, Q6IPL7, Q96RS1
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CopperMetal-binding

Cellular component

CytoplasmNucleusSecreted

Disease

DeafnessStickler syndrome

PTM

Disulfide bondGlycoproteinLTQTPQ

Biological process

Inflammatory response

Molecular function

Oxidoreductase

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignal

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