β-Tocotrienol (Standard)

• Description:

  β-Tocotrienol (Standard) is the analytical standard of β-Tocotrienol. This product is intended for research and analytical applications. β-Tocotrienol is an isomer of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol. β-Tocotrienol can be found in the tocotrienol-rich fraction (TRF) of palm oil, which possesses anti-carcinogenic effects in vitro on human colon carcinoma and prostate cancer cells. β-Tocotrienol inhibits the growth of A549 (GI50 = 1.38 μM) and U87MG (GI50 = 2.53 μM) cells. β-Tocotrienol also induces apoptosis in cancer cells. β-Tocotrienol can inhibit PD-L1 expression and mitigates PD-L1-mediated immune suppression in vitro and in vivo[1][2][3].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Leukotriene Receptor; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Apoptosis; GPCR/G Protein; Others

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/β-tocotrienol-standard.html

• Smiles:

  OC1=CC (C) =C2C (CC[C@] (CC/C=C (C) /CC/C=C (C) /CC/C=C (C) /C) (C) O2) =C1C

• Molecular Formula:

  C28H42O2

• Molecular Weight:

  410.63

• References & Citations:

  [1]A Kamal-Eldin, et al. The Chemistry and Antioxidant Properties of Tocopherols and Tocotrienols. Lipids. 1996 Jul;31 (7) :671-701.|[2]Lim, S. W., et al., (2014) . Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by β-tocotrienol in human lung and brain cancer cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68 (8), 1105–1115.|[3]Sun, Z., et al., (2022) . Inhibition of PD-L1-mediated tumor-promoting signaling is involved in the anti-cancer activity of β-tocotrienol. Biochemical and biophysical research communications, 617 (Pt 2), 33–40.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  490-23-3