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β-Tocotrienol

CAT: 0804-HY-108693-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108693-01Size:5 mg
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Description
β-Tocotrienol is an isomer of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol. β-Tocotrienol can be found in the tocotrienol-rich fraction (TRF) of palm oil, which possesses anti-carcinogenic effects in vitro on human colon carcinoma and prostate cancer cells. β-Tocotrienol inhibits the growth of A549 (GI50 = 1.38 μM) and U87MG (GI50 = 2.53 μM) cells. β-Tocotrienol also induces apoptosis in cancer cells. β-Tocotrienol can inhibit PD-L1 expression and mitigates PD-L1-mediated immune suppression in vitro and in vivo[1][2][3].
CAS Number
[490-23-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Leukotriene Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/β-tocotrienol.html
Purity
99.14
Solubility
DMSO : ≥ 50 mg/mL
Smiles
OC1=CC(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C1C
Molecular Formula
C28H42O2
Molecular Weight
410.63
Precautions
H302, H315, H319, H335
References & Citations
[1]A Kamal-Eldin, et al. The Chemistry and Antioxidant Properties of Tocopherols and Tocotrienols. Lipids. 1996 Jul;31 (7) :671-701.|[2]Lim, S. W., et al., (2014) . Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by β-tocotrienol in human lung and brain cancer cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68 (8), 1105–1115. |[3]Sun, Z., et al., (2022) . Inhibition of PD-L1-mediated tumor-promoting signaling is involved in the anti-cancer activity of β-tocotrienol. Biochemical and biophysical research communications, 617 (Pt 2), 33–40.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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