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SPTN2 rabbit pAb

CAT: 0855-ES12970-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12970-01Size:50 µL
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Background
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1) . SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
Description
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009],
UniProt
O15020
Swiss Prot
O15020
Reactivity
Human; Rat
Immunogen
Synthesized peptide derived from human SPTN2 AA range: 644-694
Target
SPTN2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Gene ID (Human)
6712

UniProtKB · O15020

Spectrin beta chain, non-erythrocytic 2

SPTN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15020
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SPTBN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O14872, O14873
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Actin cappingActin-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmCytoskeleton

Disease

Disease variantNeurodegenerationSpinocerebellar ataxia

Domain

Repeat

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