RIPK3-IN-3

• UNSPSC Description:

  RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].

• Target Antigen:

  Mixed Lineage Kinase; RIP kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ripk3-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CC1=NC=C2N=CN=C(NC3=CC(N=CS4)=C4C=C3)C2=C1

• Molecular Weight:

  305.36

• References & Citations:

  [1]Namkyoung Kim, et al. Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors. Eur J Med Chem. 2023, 259, 115635.|[2]Kim N, et al. Identification of Pyrido [3, 4-d] pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors[J]. European Journal of Medicinal Chemistry, 2023, 259: 115635...

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3052303-53-1