RIPK3-IN-5

• Description:

  RIPK3-IN-5 (compound 32) is a potent RIPK3 inhibitor with an IC50 of 27 nM. RIPK3-IN-5 also inhibits necroptosis with an EC50 of 0.45 μM[1].

• UNSPSC:

  12352101

• Target:

  Necroptosis; RIP kinase

• Related Pathways:

  Apoptosis

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CN1CCN(C2=CC=C(C3=CC4=NC=NC(NC5=C(F)C=CC=C5F)=C4C=C3)C=N2)CC1

• Molecular Formula:

  C24H22F2N6

• Molecular Weight:

  432.47

• References & Citations:

  [1]Parry C W, et al. Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras[J]. Journal of Medicinal Chemistry, 2025, 68 (9) : 9129-9161.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported