RIPK3-IN-6

• Description:

  RIPK3-IN-6 (compound 1) is a type I RIPK3 inhibitor with poor selectivity for the RIPK family, especially for RIPK2 activity[1].

• UNSPSC:

  12352203

• Target:

  RIP kinase

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Purity:

  98.03

• Solubility:

  DMSO : 31.25 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=C(C)C(NC2=CC=NC3=CC(C4=NC=CC=C4)=CC=C23)=C1

• Molecular Formula:

  C21H17N3O

• Molecular Weight:

  327.38

• References & Citations:

  [1]Rodriguez DA, et al. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ. 2016 Jan;23 (1) :76-88.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  RIPK3

• CAS Number:

  [955879-75-1]