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O4I1

CAT: 0804-HY-18771-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18771-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
O4I1 is as a potent Oct3/4 inducer. Target: Oct3/4 O4I1 enhances Oct3/4 gene expression, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. O4I1 activates Oct3/4 at the transcriptional and translational levels in diverse human cell lines. O4I1 promotes Oct3/4 expression in untransfected HEK293 cells quantified by qRT-PCR after 72 h of treatment. O4I1 is sufficient to enhance Oct3/4 overexpression 2-fold and 3-fold after 48 and 72 h of treatment, respectively.
CAS Number
175135-47-4
UNSPSC
12352005
Hazard Statement
H302
Target
Oct3/4
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/O4I1.html
Purity
98.05
Solubility
DMSO : ≥ 38 mg/mL
Smiles
N#CCC1=CC=C(OCC2=CC=C(OC)C=C2)C=C1
Molecular Formula
C16H15NO2
Molecular Weight
253.30
Precautions
H302
References & Citations
[1]Cheng X, et al. Identification of 2-[4-[ (4-Methoxyphenyl) methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58 (12) :4976-4983.|[2]Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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