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SMTIN-T140

CAT: 0804-HY-147696-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147696-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells[1].
CAS Number
2851532-40-4
UNSPSC
12352005
Target
AMPK; HSP; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smtin-t140.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(Cl)=C2C(N(C(N2CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC6=C(C=C(C=C6)Br)F)=N1
Molecular Formula
C36H34BrClFN5OP+
Molecular Weight
718.02
References & Citations
[1]Yang S, et al. Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6-chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity. Bioorg Chem. 2022 May 20;126:105856.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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