Products for Research Use Only
RegisterLogin

SMTIN-T140

CAT: 0931-T73125-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T73125-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2851532-40-4
Target
AMPK, HSP, Reactive Oxygen Species
Related Pathways
Metabolism, Cytoskeletal Signaling, NF-κB, Chromatin/Epigenetic, PI3K/Akt/mTOR signaling, Immunology/Inflammation
Bioactivity
SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 μM, exhibits anticancer activity by inducing mitochondrial dysfunction, elevating mitochondrial ROS production, and activating AMPK. Notably, SMTIN-T140 effectively suppressed tumor growth without discernible in vivo toxicity in a PC3 prostate cancer cell-xenografted mouse model [1].
Smiles
C1=CC=C(C=C1)[P+](CCCCCCN2C3=C(N=C(N=C3Cl)N)N(C2=O)CC4=C(C=C(C=C4)Br)F)(C5=CC=CC=C5)C6=CC=CC=C6
Molecular Formula
C36H34BrClFN5OP+
Molecular Weight
718.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T70270-01SMTIN-P01
T28898-01T145
T208260-01T14-A24

Alternative Products

CatalogName
HY-147696-01SMTIN-T140
GTR19209717-01SMTIN-P01

Popular Products