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T14-A24

CAT: 0804-HY-161029Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161029Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (Ki=22 nM, IC50=6 nM) . T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile[1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/t14-a24.html
Solubility
10 mM in DMSO
Smiles
O=S(CCC1=CN(N=N1)C2=CC3=CC=CC=C3N=C2)(NCCC4=CNC5=C4C=C(OC)C=C5)=O
Molecular Formula
C24H24N6O3S
Molecular Weight
476.55
References & Citations
[1]Tang K, et al. Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2237213.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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