(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH

(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH

• UNSPSC Description: (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand and linker of the E3 ubiquitinase VH032. The Linker of (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH can further be linked to target protein ligands (such as BCR-ABL1) to form PROTAC molecules[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-me-piperazine-acetyl-pip-acoh.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CN4CCN(CC(N5CCNCC5)=O)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1
• Molecular Weight: 696.90
• References & Citations: [1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres. 1236. 2019
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported