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Chelidamic acid

CAT: 0804-HY-W016349-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W016349-01Size:1 g
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Description
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
CAS Number
138-60-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amino Acid Decarboxylase
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Chelidamic_acid.html
Purity
99.93
Solubility
DMSO : 10 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C=C(C(O)=O)N1)=O)O
Molecular Formula
C7H5NO5
Molecular Weight
183.12
Precautions
H315, H319, H335
References & Citations
[1]Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13 (8) :837-55.|[2]Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39 (16) :3645-51.|[3]Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34 (23) :4145-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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