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Aplodan

CAT: 0804-HY-107335-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107335-02Size:50 mg
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Description
Aplodan (Creatinol O-phosphate) is an antiischemic and antiarrhythmic agent. Aplodan has a protective action on cell membrane. Aplodan has the potential for the research of ischemic heart or acute myocardial infarction [1][2][3][4][5][6].
CAS Number
6903-79-3
Product Name Alternative
Creatinol O-phosphate; Creatinol phosphate; Creatinolfosfate
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H332-H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aplodan.html
Purity
99.20
Solubility
H2O : 62.5 mg/mL (ultrasonic)
Smiles
N=C(N)N(C)CCOP(O)(O)=O
Molecular Formula
C4H12N3O4P
Molecular Weight
197.13
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Botti G, et al. Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects. Arzneimittelforschung. 1979;29 (9a) :1491-1494.|[2]Di Maio F, et al. Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial. Arzneimittelforschung. 1979;29 (9a) :1488-1490.|[3]Knippel M, et al. Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction. Arzneimittelforschung. 1979;29 (9a) :1480-2.|[4]Godfraind T, et al. An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat. Arzneimittelforschung. 1979;29 (9a) :1457-64. |[5]Marchetti G, et al. Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs. Arzneimittelforschung. 1978;28 (10) :1708-11. |[6]Olsen JI, et al. A 31P NMR spectroscopy study of Xenopus laevis heart perfused in vitro with creatinol-O-phosphate, phosphocreatine, adenosine triphosphate, fructose diphosphate and ouabain. Pharmacol Res. 1993 Sep;28 (2) :135-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Creatinolfosfate

Creatinolfosfate is a phosphoethanolamine.

CAS Number6903-79-3
PubChem CID23342
IUPAC Name2-[carbamimidoyl(methyl)amino]ethyl dihydrogen phosphate
Molecular FormulaC4H12N3O4P
Molecular Weight197.13
XLogP-2.5
Topological Polar Surface Area120
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count12
Formal Charge0
Complexity202
SMILES
CN(CCOP(=O)(O)O)C(=N)N
InChI
InChI=1S/C4H12N3O4P/c1-7(4(5)6)2-3-11-12(8,9)10/h2-3H2,1H3,(H3,5,6)(H2,8,9,10)
InChIKey
FOIPWTMKYXWFGC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Creatinolfosfate
CAS: 6903-79-3
CID: 23342
Formula: C4H12N3O4P
MW: 197.13
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight197.13
XLogP3-2.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass197.05654287
Monoisotopic Mass197.05654287
Topological Polar Surface Area120 Ų
Heavy Atom Count12
Formal Charge0
Complexity202
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19172388-01Aplodan

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