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Aplodan

CAT: 0804-HY-107335-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107335-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aplodan (Creatinol O-phosphate) is an antiischemic and antiarrhythmic agent. Aplodan has a protective action on cell membrane. Aplodan has the potential for the research of ischemic heart or acute myocardial infarction [1][2][3][4][5][6].
CAS Number
6903-79-3
Product Name Alternative
Creatinol O-phosphate; Creatinol phosphate; Creatinolfosfate
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H332-H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aplodan.html
Purity
99.20
Solubility
H2O : 62.5 mg/mL (ultrasonic)
Smiles
N=C(N)N(C)CCOP(O)(O)=O
Molecular Formula
C4H12N3O4P
Molecular Weight
197.13
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Botti G, et al. Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects. Arzneimittelforschung. 1979;29 (9a) :1491-1494.|[2]Di Maio F, et al. Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial. Arzneimittelforschung. 1979;29 (9a) :1488-1490.|[3]Knippel M, et al. Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction. Arzneimittelforschung. 1979;29 (9a) :1480-2.|[4]Godfraind T, et al. An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat. Arzneimittelforschung. 1979;29 (9a) :1457-64. |[5]Marchetti G, et al. Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs. Arzneimittelforschung. 1978;28 (10) :1708-11. |[6]Olsen JI, et al. A 31P NMR spectroscopy study of Xenopus laevis heart perfused in vitro with creatinol-O-phosphate, phosphocreatine, adenosine triphosphate, fructose diphosphate and ouabain. Pharmacol Res. 1993 Sep;28 (2) :135-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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