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ODN 1826

CAT: 0804-HY-146245-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146245-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ODN 1826 is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 induces NO and iNOS production and enhances Apoptosis. ODN 1826 enhances immune surveillance. ODN 1826 increases aortic atherosclerotic plaque size. ODN 1826 has antitumor activity against lung cancer, glioma and melanoma[1][2][3][4][5][6].
CAS Number
202668-42-6
Product Name Alternative
CpG 1826
UNSPSC
12352208
Target
Apoptosis; NO Synthase; Toll-like Receptor (TLR)
Type
Oligonucleotides
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/odn-1826.html
Purity
99.76
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[ODN1826]
Molecular Weight
6364.10
References & Citations
[1]Hou Y, et al. Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells. J Agric Food Chem. 2019 Jul 24;67 (29) :8227-8234.|[2]Qi XF, et al. CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways. Mol Immunol. 2013 Jul;54 (3-4) :327-37. |[3]Utaisincharoen P, et al. CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7) . Clin Exp Immunol. 2002 Jun;128 (3) :467-73.|[4]Jordan M, et al. CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model. Cancer Lett. 2016 Apr 1;373 (1) :88-96.|[5]Krogmann AO, et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One. 2016 Jan 11;11 (1) :e0146326. |[6]Yuan S, et al. CpG oligodeoxynucleotide 1826 enhances the Lewis lung cancer response to radiotherapy in murine tumor. Cancer Biother Radiopharm. 2011 Apr;26 (2) :203-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
TLR9
Citation 01
ACS Appl Mater Interfaces. 2024 Jul 31;16 (30) :39153-39164.|Adv Mater. 2025 Sep 1:e02375.|Biochem Biophys Res Commun. 2024 Apr 16:704:149661.|Hepatology. 2025 Nov 7.|Life Sci. 2025 Aug 29:380:123930.|Nano Today. 2025 Oct.|Neurochem Res. 2025 Sep 5;50 (5) :288.|Research Square Preprint. 2024 Dec 18.

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