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ODN M362

CAT: 0804-HY-150750-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150750-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ODN M362, a class C oligodeoxynucleotide, is a TLR-9 agonist and can be used as a vaccine adjuvant. ODN M362 induces cancer cell apoptosis[1][2].
CAS Number
934655-87-5
UNSPSC
12352208
Target
Apoptosis; Toll-like Receptor (TLR)
Type
Oligonucleotides
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/odn-m362.html
Purity
96.01
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[DNA,d(P-thio)(T-C-G-T-C-G-T-C-G-T-T-C-G-A-A-C-G-A-C-G-T-T-G-A-T)]
Molecular Weight
8049.50
References & Citations
[1]Babaer D, et al. Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel) . 2019 May 14;11 (5) :672.|[2]Zhang Y, et al. Phosphorothioate-modified CpG oligodeoxynucleotide (CpG ODN) induces apoptosis of human hepatocellular carcinoma cells independent of TLR9. Cancer Immunol Immunother. 2014 Apr;63 (4) :357-67.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
TLR9