Human Eotaxin-2/CCL24 (Recombinant)

• Description:

  Human Eotaxin-2/CCL24_x000D_ Catalog number: B2010354_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Volume/Weight: 10 ug_x000D_ pH: 7.4 upon reconstitution_x000D_ Supplied as: Lyophilized Powder_x000D_ Appearance: Powder_x000D_ Applications: highly pure Human Eotaxin-2/CCL24 expressed in E. coli. This protein acts as a chemoattractant for CCR3-bearing cells such as eosinophils, mast cells, basophils, and Th2 cells that play a role in allergic disorders._x000D_ Storage: -20C_x000D_ Keywords: rHuEotaxin-2/CCL24; C-C motif chemokine 24; CK-beta-6; MPIF-2; MPIF2; SCYA24_x000D_ Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Kohan M, Puxeddu I, Reich R, Levi-Schaffer F, Berkman N. Eotaxin-2/CCL24 and_x000D_ eotaxin-3/CCL26 exert differential profibrogenic effects on human lung_x000D_ fibroblasts. Ann Allergy Asthma Immunol. 2010 Jan;104(1):66-72._x000D_ _x000D_ 2: Yoshida N, Aizu-Yokota E, Sonoda Y, Moriwaki Y, Kishi K, Kasahara T._x000D_ Production and regulation of eotaxin-2/CCL24 in a differentiated human leukemic_x000D_ cell line, HT93. Biol Pharm Bull. 2007 Oct;30(10):1826-32._x000D_ _x000D_ 3: Miyagawa Y, Murakami A, Ebihara N. The proteolytic effect of mast cell_x000D_ tryptase to eotaxin-1/CCL11·eotaxin-2/CCL24 and eotaxin-3/CCL26 produced by_x000D_ conjunctival fibroblasts. Jpn J Ophthalmol. 2019 Mar;63(2):215-220._x000D_ _x000D_ 4: Menzies-Gow A, Ying S, Sabroe I, Stubbs VL, Soler D, Williams TJ, Kay AB._x000D_ Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils,_x000D_ basophils, neutrophils, and macrophages as well as features of early- and late-_x000D_ phase allergic reactions following cutaneous injection in human atopic and_x000D_ nonatopic volunteers. J Immunol. 2002 Sep 1;169(5):2712-8._x000D_ _x000D_ 5: Kagami S, Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Nakamura K, Takekoshi T,_x000D_ Kishimoto M, Mitsui H, Torii H, Komine M, Asahina A, Tamaki K. Significant_x000D_ elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in_x000D_ patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the_x000D_ disease activity of atopic dermatitis. Clin Exp Immunol. 2003 Nov;134(2):309-13._x000D_ _x000D_ 6: Heiman AS, Abonyo BO, Darling-Reed SF, Alexander MS. Cytokine-stimulated_x000D_ human lung alveolar epithelial cells release eotaxin-2 (CCL24) and eotaxin-3_x000D_ (CCL26). J Interferon Cytokine Res. 2005 Feb;25(2):82-91._x000D_ _x000D_ 7: Komiya A, Nagase H, Yamada H, Sekiya T, Yamaguchi M, Sano Y, Hanai N, Furuya_x000D_ A, Ohta K, Matsushima K, Yoshie O, Yamamoto K, Hirai K. Concerted expression of_x000D_ eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells. Cell_x000D_ Immunol. 2003 Oct;225(2):91-100._x000D_ _x000D_ 8: Schaefer D, Meyer JE, Pods R, Pethe W, Hedderich J, Schmidt C, Maune S._x000D_ Endothelial and epithelial expression of eotaxin-2 (CCL24) in nasal polyps. Int_x000D_ Arch Allergy Immunol. 2006;140(3):205-14._x000D_ 9: Pham TH, Damera G, Newbold P, Ranade K. Reductions in eosinophil biomarkers_x000D_ by benralizumab in patients with asthma. Respir Med. 2016 Feb;111:21-9._x000D_ _x000D_ Products Related to Human Eotaxin-2/CCL24 : Proteins

• Short Description:

  Catalog Number: B2010354 (10 ug)_x000D_ Human Eotaxin-2/CCL24 is a high quality research product used as highly pure Human Eotaxin-2/CCL24 expressed in E. coli. This protein acts as a chemoattractant for CCR3-bearing cells such as eosinophils, mast cells, basophils, and Th2 cells that play a role in allergic disorders. Custom bulk orders of this product are available upon request.

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3