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TL4-12

CAT: 0804-HY-123714-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123714-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM) [1].
CAS Number
1620820-12-3
UNSPSC
12352005
Target
Apoptosis; MAP4K
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tl4-12.html
Purity
99.82
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C(OC2=NC=NC(NC)=C2)=C1)C)NC3=CC(C(F)(F)F)=CC(N4CCN(CC4)C)=C3
Molecular Formula
C25H27F3N6O2
Molecular Weight
500.52
References & Citations
[1]Shirong Li, et al. Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma. Blood. 2021 Apr 1;137 (13) :1754-1764.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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