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Lenalidomide-C5-amido-Boc

CAT: 0804-HY-132856-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132856-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC[1].
CAS Number
2138441-25-3
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-c5-amido-boc.html
Purity
95.10
Solubility
DMSO : 90 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)NCCCCCC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O
Molecular Formula
C23H31N3O5
Molecular Weight
429.51
References & Citations
[1]Wang, Shaomeng, et al. Preparation of phthalimide-based compounds as monofunctional intermediates for ligand-dependent target protein degradation. World Intellectual Property Organization, WO2017176958 A1 2017-10-12.|[2]Robbins, Daniel, et al. WBifunctional compounds for degrading BTK via ubiquitin proteasome pathway. World Intellectual Property Organization, WO2021091575 A1 2021-05-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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