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GSK'872

CAT: 1568-C13436-10mM/1mLSize: 10 mm/ 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C13436-10mM/1mLSize:10 mm/ 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1346546-69-7
Synonyms
GSK2399872A
Target
RIP kinase
Applications
Apoptosis
Smiles
CC (C) S (=O) (=O) C1=CC2=C (C=CN=C2C=C1) NC3=CC4=C (C=C3) SC=N4
Molecular Formula
C19H17N3O2S2
Additionnal Information
GSK'872 is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.
Storage Conditions
2 years -80 in solvent

Chemical Information

Gsk872

A selective RIP3 inhibitor

CAS Number1346546-69-7
PubChem CID54674134
IUPAC NameN-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
Molecular FormulaC19H17N3O2S2
Molecular Weight383.5
XLogP4.2
Topological Polar Surface Area109
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity592
SMILES
CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4
InChI
InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)
InChIKey
ZCDBTQNFAPKACC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gsk872
CAS: 1346546-69-7
CID: 54674134
Formula: C19H17N3O2S2
MW: 383.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight383.5
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass383.07621914
Monoisotopic Mass383.07621914
Topological Polar Surface Area109 Ų
Heavy Atom Count26
Formal Charge0
Complexity592
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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T4074-01GSK-872
2673-5GSK'872
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A19871-500GSK-872 500mg
A19871-50GSK-872 50mg
GTR19169176-01GSK 872 hydrochloride
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