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CK-666

CAT: 1568-C12876-10mM/1mLSize: 10 mm/ 1 mLDry Ice: NoHazardous: No
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CAT#:1568-C12876-10mM/1mLSize:10 mm/ 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
442633-00-3
Target
Actin
Applications
Cytoskeletal Signaling
Smiles
CC1=C (CCNC (=O) C2=CC=CC=C2F) C3=C ([NH]1) C=CC=C3
Molecular Formula
C18H17FN2O
Additionnal Information
CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex with IC50 of 17 μM and 5 μM for BtArp2/3 complex and SpArp2/3 complex, respectively.
Storage Conditions
3 years -20°C powder

Chemical Information

CK-666

CK-666 is a member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. It has a role as an actin polymerisation inhibitor. It is a member of benzamides, a member of indoles and an organofluorine compound.

CAS Number442633-00-3
PubChem CID589075
IUPAC Name2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Molecular FormulaC18H17FN2O
Molecular Weight296.3
XLogP3.8
Topological Polar Surface Area44.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity389
SMILES
CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F
InChI
InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChIKey
UXRKUKRXVWJFER-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CK-666
CAS: 442633-00-3
CID: 589075
Formula: C18H17FN2O
MW: 296.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.3
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass296.13249133
Monoisotopic Mass296.13249133
Topological Polar Surface Area44.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity389
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B5500-10CK 666
T10826-01CK-666
A20973-200CK-666 200mg
A20973-10CK-666 10mg
A20973-100CK-666 100mg
A20973-25CK-666 25mg
A20973-5CK-666 5mg
A20973-50CK-666 50mg
A20973-1CK-666 1mg

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